Ricevimento: Lunedi 10.30-12.30
CuriculumVitae et Studiorum
Curriculum breve Permanent Research in Physiology at University of Calabria(UNICAL). 2014 National Scientific Qualification to Associate Professor in Physiology. PhD in Animal Biology(Cardiovascular Physiology)-UNICAL and in Molecular and Cellular Aspects of Biology at INSERM575-University Pasteur(Strasbourg, France). Scientific director of the Lab. of Cardiovascular Pathophysiology (Dept. DiBEST-UNICAL). Membership: Scientific Board of Doctorate Fellowship in Life Sciences-UNICAL, Scientific Board of Italian Society for Cardiovascular Research, member of Italian Physiological Society, Italian Institute for Cardiovascular Research, International Society of Heart Research. Recent Projects Participation: From 2011: Participation to the Research Program PON01_00937: “Modelli sperimentali Biotecnologici integrati per lo sviluppo e la selezione di molecole di interesse per la salute dell’uomo” ; From 2011: Participation to the Research Program PON01_00293: ““Sviluppo di nuovi processi tecnologici per la produzione di emulsioni innovative a base d’olio d’oliva biologico a consistenza controllata” acronimo “Spread Bio-oil” ; Italian Research Program 2008; Research Project for “young researchers”; “Vinci Programme” and “Galileo Programme” with INSERM575-France.Awards.2013: SIRC; 2012: Italian Physiological Society; 2010-2011: SIRC;2005: INRC;2003:SIRC.Collaborations: Dr.Metz-Boutigue(INSERM,France); Dr.Loh(NIH,USA); Dr. Corti (San Raffaele Institute,Milan); Prof. Mahata (University of San Diego,USA); Proff. Pagliaro, Alloatti (Univerity of Turin). Dr. Angelone's research is focused on the endocrine/paracrine/autocrine mechanisms which contribute to regulate cardiac performance at cellular, tissue and organ level, with particular regard to the role of Neuropeptides. Results, obtained with a multilevel approach (i.e.Langendorff analysis of the cardiac performance, cardiomyocytes cultures, differential proteomic, immunolocalization etc.), have enlarged the knowledge on the circuits which sustain cardiac homeostasis under normal condition and in the presence of physio-pathologic stress, with notable biomedical relevance. Dott.Angelone was Guest co-Editor of a Special Volume on CMC(2012) and is reviewer of manuscripts submitted for publication in the several International Journals (ISI) such as: Journal of Cellular Physiology; JPET,EJP,etc. Dr.Angelone is author and co-author of 42 full papers (ISI Journals) and 106 in proceeding and meeting partecipations.
Dr. Angelone’s research is focused on the endocrine/paracrine/autocrine mechanisms which contriute to regulate cardiac performance at cellular, tissue and organ level, with particular regard to the role of Nitric Oxide and its transducion mechanisms. Results have enlarged the knowledge on the circuits which sustain cardiac homeostasis under normal condition and in the presence of physio-pathologic stress, with notable biomedical relevance. In particular, Dr. Angelone’s research described the negative inotropism and lusitropism elicited by Chromogranin-A (CGA)-derived peptides which is elicited via activation of the NO pathway. Moreover, Dr. Angelone observed that this proteic precursor is present in the human hypertrophic and dilated ventricular myocardium, in which it co-localizes with BNP. Moreover, he found that, at cardiac level, this protein is cleaved into bioactive fragments. These peptides protect the myocardium like ischemic preconditioning and traditional donors of nitric oxide. Since in chronic heart failure circulating CgA increases depending on the severity of the disease, also being an independent prognostic indicator of mortality, results on CgA fragments are of notable basic and biomedical-clinical interest. Of note, Dr. Angelone described in the rat heart the negative lusitropism elicited by the beta3-adrenergic receptor subtype and the cross-talk with the NO cascade. Results, obtained with a multilevel approach (i.e. Langendorff analysis of the cardiac performance, cardiomyocytes cultures, differential proteomic, immunolocalization etc.), have enriched the knowledge on the humoral circuits which sustain cardiac homeostasis under both normal conditions and physio-pathological challenges (i.e. stress).